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针对EP2/EP4可以防止cDC2s中由瘤衍生的PGE2介导的免疫抑制

Jorge Cuenca-Escalona1, Johanna Bödder1, Beatriz Subtil1

  • 1Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands.

Journal of leukocyte biology
|July 23, 2024
PubMed
概括

来自瘤的前列腺素E2 (PGE2) 通过影响树突细胞 (DCs) 抑制抗瘤免疫力. 纳米颗粒封装的EP2/4对抗剂保护了DCs免受PGE2的影响,增强了抗癌免疫反应.

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