内源性葡萄皮质类药物对于正常的巨细胞激活和胃杆菌免疫是必需的
Stuti Khadka1, Sebastian A Dziadowicz1, Xiaojiang Xu2
1Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, West Virginia, United States.
概括
葡萄糖皮质体信号发送使巨细胞能够防御病原体,但限制了有害的炎症. 破坏这种信号会损害对Helicobacter pylori的免疫反应,从而保护小鼠免受胃炎的影响.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 微生物学 微生物学
背景情况:
- 葡萄糖皮质类药物具有强大的抗炎作用,但它们在免疫系统中的作用是复杂的.
- 新出现的证据表明,葡萄糖皮质体信号传递对于有效的免疫力至关重要,而其破坏会损害免疫功能.
研究的目的:
- 为了研究葡萄糖皮质体受体 (GR) 在髓状细胞中在Helicobacter pylori感染期间信号传递的作用.
- 为了确定GR缺失在巨细胞对免疫反应和胃病理学的影响.
主要方法:
- 使用LysM-Cre驱动器 (myGRKO小鼠) 在骨髓细胞中条件删除葡萄糖皮质体受体 (GR).
- 对巨细胞激活,基因表达和染色体景观的分析.
- 在WT和myGRKO小鼠中,评估胃免疫反应和H. pylori挑战后的病理学.
主要成果:
- 在细菌挑战时,GRKO巨细胞显示染色质调节失调和阻燃性炎症基因表达受损.
- myGRKO小鼠表现出胃免疫反应降低和T细胞对H. pylori的招募.
- myGRKO小鼠受到了H.pylori诱导的缩性胃炎和pyloric metaplasia的保护.
结论:
- 葡萄皮质皮质体信号传递起着双重作用:在预防过度炎症的同时,对巨细胞进行感染的初始化.
- 巨细胞对于对H.pylori的胃免疫是至关重要的.
- 巨细胞中GR信号的破坏会影响宿主防御和H. pylori感染的发病.
相关概念视频
Immune Surveillance by NK Cells and Phagocytes
1.4K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.4K
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
362
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
362
Inflammatory Response
1.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.9K
Antigens Involved in Adaptive Immunity
479
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
479
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Cell-mediated Immune Responses
68.0K
Overview
68.0K


