孕妇静脉血栓栓塞相关的危险因素:一个元分析
Lianci He1, Jianhua Liu2, Rong Sun1
1Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
概括
怀孕增加了静脉血栓栓塞 (VTE) 的风险. 剖腹产,妊娠期糖尿病,肥胖和慢性心脏病被确定为孕妇的关键危险因素.
科学领域:
- 产科和妇科 产科和妇科
- 心脏病学 心脏病学
- 血液学 血液学 血液学
背景情况:
- 静脉血栓塞栓症 (VTE) 在怀孕期间存在重大风险.
- 在孕妇中确定VTE风险因素对于临床管理至关重要.
研究的目的:
- 进行初步的元分析,确定孕妇VTE的危险因素.
- 综合现有关于怀孕中静脉瘤风险的证据.
主要方法:
- 在PubMed,Web of Science和NLM数据库进行系统的文献搜索,截至2023年1月1日.
- 统计分析了使用RevMan5.3软件的10项研究数据.
- 分析重点关注了16个已识别的风险因素.
主要成果:
- 剖腹产 (OR=2.05),孕期糖尿病 (OR=1.17),阴/孕前阴 (OR=1.88),肥胖 (OR=1.19),双胞胎/多胎怀孕 (OR=2.34),慢性心脏病 (OR=3.59),以及血液输血史 (OR=3.20) 是静脉动脉瘤的重要危险因素.
- 分析包括10项研究,并评估了22种潜在的风险因素.
- 所有确定的风险因素都显示出在怀孕期间与VTE的统计学上显著的关联.
结论:
- 剖腹产,孕期糖尿病,黄昏症/孕前黄昏症,肥胖 (BMI ≥30 kg/m2),多胎妊娠,慢性心脏病和输血史是孕妇潜在的静脉突发症风险因素.
- 建议加强临床实践中的VTE评估和管理.
- 开发怀孕期间VTE的临床预测模型可以帮助预防工作.
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