从反复流感疫苗接种暴露 (DRIVE I) 免疫反应的动力学初步发现研究:一个随机对照试验
Benjamin J Cowling1,2, Sook-San Wong1,3, Jefferson J S Santos4
1WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
概括
成年人每年接种流感疫苗时,在第一次接种和重复接种疫苗的患者中显示出类似的抗体反应. 这表明,无论先前的疫苗接种史,临床保护是可比的,支持当前的疫苗接种策略.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 每年重复接种流感疫苗对疫苗有效性的影响也在讨论中.
- 了解接种疫苗后免疫反应对公共卫生战略至关重要.
研究的目的:
- 为了评估成年人每年重复接种流感疫苗的免疫性.
- 为了比较两年内第一次接种和重复接种疫苗的抗体反应.
主要方法:
- 这是一项为期5年的随机化安慰剂受控试验,涉及18-45岁的成年人.
- 参与者每年接受Flublok疫苗或盐水安慰剂.
- 在多个时间点测量了针对疫苗菌株的血清抗体标位.
主要成果:
- 接种疫苗后抗体标位增加,在第二年重复接种疫苗的患者中,接种前的抗体标位较高.
- 对某些菌株 (A(H1N1),B/Victoria,B/Yamagata) 抗体增加≥4倍的统计学显著差异,但不是A(H3N2).
- 在第二年,在安慰剂-疫苗和疫苗-疫苗组之间没有发现几何平均标位或达到标位≥40的比例的显著差异.
结论:
- 在没有流传性流感的情况下,重复接种和首次接种疫苗的人表现出类似的疫苗接种后抗体标位.
- 这些发现表明,不同组的临床保护水平相似.
- 这项研究支持每年接种流感疫苗的有效性,无论之前的疫苗接种历史如何.
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