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相关概念视频

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Development of Immunocompetence01:22

Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Immunological Memory01:23

Immunological Memory

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Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
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相关实验视频

Updated: Jun 19, 2025

Isolation and Transplantation of Different Aged Murine Thymic Grafts.
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Isolation and Transplantation of Different Aged Murine Thymic Grafts.

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胸膜微环境对免疫衰变的影响

Li Li1, Feng Xu1, Yi Han1

  • 1Shenzhen Guangming District People's Hospital, 4253 Songbai Road, Matian Street, Guangming District, Shenzhen, 518106, Guangdong, China.

Immunologic research
|July 23, 2024
PubMed
概括

随着年龄的增长,甲状腺缩会损害T细胞的发育. 移植胎儿胸腺组织逆转了这种衰退,恢复了T细胞的产生,并表明胸腺微环境驱动了与年龄相关的免疫功能障碍.

关键词:
与年龄相关的胸膜内变.免疫衰变的起源胸膜上皮细胞 胸膜上皮细胞胸膜微环境是一个微环境.甲状腺发育 甲状腺发育

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Isolation, Identification, and Purification of Murine Thymic Epithelial Cells
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Isolation, Identification, and Purification of Murine Thymic Epithelial Cells

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相关实验视频

Last Updated: Jun 19, 2025

Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

13.8K
Isolation, Identification, and Purification of Murine Thymic Epithelial Cells
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Isolation, Identification, and Purification of Murine Thymic Epithelial Cells

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Preparation and Applications of Organotypic Thymic Slice Cultures
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科学领域:

  • 免疫学 免疫学 免疫学
  • 衰老研究研究 衰老研究
  • 细胞生物学 细胞生物学

背景情况:

  • 与年龄相关的胸膜内置导致T细胞发育减少和免疫功能下降.
  • 衰老会损害淋巴血液构造原始细胞,包括早期T细胞原始细胞 (ETP),从而导致胸腺内置.
  • 胸膜微环境在T细胞发育和化过程中起着至关重要的作用.

研究的目的:

  • 调查胸膜微环境在与年龄相关的胸膜发育中的作用.
  • 为了确定在胸膜微环境中与年龄相关的变化背后的机制.
  • 通过胸腺移植来评估这些与年龄相关的变化的可逆性.

主要方法:

  • 将T细胞枯竭的胎儿胸腺组织移植到老老鼠体内.
  • 流细胞计用于分析原始的T细胞群 (CD62L+CD44-).
  • 实时PCR测量T细胞受体切除循环并评估基因表达.

主要成果:

  • 胎儿胸腺移植改善了老年小鼠的胸腺输出和T细胞生产.
  • 移植逆转了因胸膜内置引起的T细胞发育障碍.
  • 在ETPs中观察到重建关键细胞因子的表达和正常的胸膜T细胞发育.

结论:

  • 胸膜微环境的退行性变化是与年龄相关的胸膜功能障碍的主要原因.
  • 胸膜微环境功能障碍对免疫性产生有显著的贡献.
  • 胎儿胸腺移植提供了一种潜在的策略,可以逆转与年龄相关的胸腺内置并恢复免疫功能.