在微创性结肠直肠癌手术后,针对长期结核的个性化风险预测:深入的风险因素分析和模型开发
Wenchao Xiu1, Yalin Zhang2, Yifan Man3
1Department of Anorectal Center, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, 266035, Shandong, China.
International journal of colorectal disease
|July 23, 2024
概括
这项研究确定了经过微创性结肠直肠癌手术后长期术后阴茎损伤 (PPOI) 的关键风险因素. 一个新的名图有助于预测个体PPOI风险,从而实现个性化预防策略,以获得更好的患者结果.
科学领域:
- 结肠直肠外科手术是什么意思
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 对于结肠直肠癌 (CRC) 最少侵入性手术是首选的,但长期的术后阴茎 (PPOI) 仍然是一个挑战.
- 识别患有PPOI高风险的患者对于优化手术结果至关重要.
研究的目的:
- 在接受微创性CRC手术 (MICRS) 的患者中确定PPOI的独立风险因素.
- 开发和验证一个名图,用于预测MICRS后的个人PPOI风险.
主要方法:
- 对2368名接受MICRS.治疗的患者进行了回顾性分析.
- 在训练队列 (1895名患者) 上使用多变量逻辑回归开发名录 (1895名患者).
- 编号的内部和外部验证.
主要成果:
- 在9.5%的患者中发生PPOI.
- 确定了六个独立的风险因素:晚年,男性性别,高并发症指数,手术前的肉症,低预后营养指数和手术期间的液体过载.
- 诺米图表表现出高预测准确度 (AUC 0.887 和 0.838) 和出色的校准.
结论:
- 一个集成的名图有效地预测了MICRS后的PPOI风险.
- 个性化风险预测允许定制的预防策略.
- 这种工具的实施可以改善CRC的MICRS患者的治疗结果.
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