柏柏林是否会影响代谢功能障碍相关的脂肪肝病患者的人体,肝脏和代谢参数? 随机,双盲,安慰剂受控试验随机,双盲,安慰剂受控试验
A Koperska1,2, M Moszak3, A Seraszek-Jaros4
1Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Poznan, Poland. anna.koperska@student.ump.edu.pl.
概括
柏柏林 (BBR) 补充剂在治疗与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 中表现有前途. 一项为期12周的试验发现,与安慰剂相比,BBR显著降低了肝酶,改善了总胆固醇.
科学领域:
- 肝病学和代谢障碍 肝病和代谢障碍
- 临床营养和营养保健品
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是全球最常见的慢性肝病.
- 柏柏林 (BBR) 是一种天然化合物,在治疗肥胖,肝硬化和代谢障碍方面表现出潜力.
研究的目的:
- 调查柏柏林 (BBR) 在改善与MAFLD相关的关键因素方面的疗效.
- 评估BBR补充剂对MAFLD患者人体,肝脏和代谢参数的影响.
主要方法:
- 一个为期12周的随机,双盲,安慰剂控制的临床试验,涉及70名被诊断患有MAFLD的人.
- 参与者被分配给每天服用1500毫克口服BBR或安慰剂.
- 评估人体测量,肝脏 (ALT,AST,de Ritis比),脂质,葡萄糖和脂肪肝指数 (FLI) 的参数.
主要成果:
- 与安慰剂组相比,BBR组表现出氨酸转氨酶 (ALT) 和de Ritis比率的显著降低.
- 两组都显示出干脂肪的减少,但只有BBR组显示出总胆固醇水平的显著改善.
- 在BBR组中,在BMI,体内脂肪,de Ritis比率,FLI和代谢标志物 (ALT,AST,HOMA-IR,VAI,FIB-4) 的变化之间观察到显著的相关性.
结论:
- 柏柏林 (BBR) 显示出作为一种生物活性化合物的潜力,可以对MAFLD产生积极影响.
- 需要进行更长的干预期的进一步研究,以充分确定BBR在MAFLD管理中的疗效和临床效用.
相关概念视频
01:24Overview of Lipid Metabolism
1.3K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.3K
01:19Factors Affecting Drug Biotransformation: Biological
135
Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
135
01:21Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs
222
A drug's physicochemical properties fundamentally influence its metabolism. For instance, a drug's molecular size and shape critically determine its interaction with enzymes and transporters — larger drugs may face difficulty reaching enzyme active sites, altering their metabolic pathways. The pKa of a drug, which establishes its ionization state, can impact its solubility and absorption, thereby influencing metabolism.
The drug's acidity or basicity is essential in...
The drug's acidity or basicity is essential in...
222
01:30Liver Physiology
489
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
489
01:19Overview of Carbohydrate Metabolism
864
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
864
01:29Cholesterol: Significance and Regulation
527
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
527