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Updated: Jun 19, 2025

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构建用于低毒瘤光疗的无重原子光敏感剂,基于由捐赠者激发的光诱导电子转移驱动的I型和II型机制

Junfeng Miao¹, Guangxiao Yao¹, Yingying Huo¹

¹School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China.

ACS applied materials & interfaces

|July 23, 2024

概括

这项研究引入了新的无重原子光敏感剂,用于癌症治疗,使用新的捐赠者激发电子转移机制. 这些药物在近红外光下产生多种反应性氧物种,显示出对瘤的高疗效.

科学领域:

光动力学疗法光动力学疗法
有机化学有机化学
材料科学材料科学材料科学

背景情况:

旋转轨道电荷转移系统间交叉 (SOCT-ISC) 是光动力学疗法 (PDT) 中无重原子光敏感剂 (PSs) 的关键.
现有的PS主要使用受体激发的光诱导电子转移 (a-PeT) 来驱动SOCT-ISC.
需要替代机制来扩大PS设计以提高治疗结果.

研究的目的:

为瘤PDT开发新的无重原子PS.
首次利用由供体激发的光诱导电子转移 (d-PeT) 驱动的SOCT-ISC机制.
调查这些新PS的双重Type-I和Type-II反应性氧物种生成能力.

主要方法:

通过将缺电子的N-alkylquinolinium单元纳入近红外的distyryl Bodipy核心来合成新的PSs.
研究了不同环境中的光物理性质和作用机制 (不太极地与水性).
评估了近红外辐射下癌细胞的细胞吸收,反应性氧物种产生和光细胞毒性.

主要成果:

成功演示了d-PeT驱动的SOCT-ISC机制用于PS建设.
PSs表现出单体氧 (II型) 在单体形式和超氧化物/基 (I型) 在纳米聚合物的环境依赖生成.
在normoxia和hypoxia下实现了快速内化到癌细胞和强烈的光细胞毒性 (IC50 <1μM).
开发了一种可向瘤的PS,具有经过验证的体外和体内瘤除能力.

结论:

由d-PeT驱动的SOCT-ISC机制为设计有效的无重原子PSS提供了新的途径.
这些PS表现出多功能反应性氧物种的产生,使得强大的双重I型/II型光动力学疗法.
开发的PS平台显示了针对性癌症治疗的显著前景,对正常组织的损害最小.

关键词:

没有重原子的重原子.接近红外线的近红外线光动力学疗法光动力学疗法照片诱导的电子转移光敏化剂是一种光敏化剂.瘤是一个瘤.

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