肝酶与老年人认知表现的非线性关联:一个横截面研究
Yan-Li Zhang1, Shi-Ying Jia2, Bo Yang3
1Department of Neurological Intensive Care Unit, Sixth Hospital of Shanxi Medical University (General Hospital of Tisco), Taiyuan, Shanxi, China.
PloS one
|July 23, 2024
概括
像性酸酶 (ALP) 和AST/ALT比率这样的肝酶与认知表现有关. 维持肝酶水平在特定范围内可能有助于降低认知障碍的风险.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 肝病学 肝病学是一种肝病学.
背景情况:
- 肝脏代谢功能障碍是认知障碍和痴呆症的潜在危险因素.
- 关于肝酶与认知表现之间的非线性关联的证据仍然有限.
研究的目的:
- 为了研究关键肝酶与老年人认知表现之间的非线性关系.
- 为了确定与认知障碍风险相关的肝酶的特定值.
主要方法:
- 从NHANES (2011-2014) 对2764名年龄≥60岁的成年人进行的横截面研究.
- 评估肝酶 (ALP,AST,ALT,AST/ALT比,GGT) 和认知表现 (AFT,CERAD,DSST) 的情况.
- 利用加权后勤回归,通用添加模型和顺曲线来分析关联和值效应.
主要成果:
- 酸酸酶 (ALP) 与动物流利性测试 (AFT) 成绩负相关.
- AST/ALT比率与全球认知,CERAD和数字符号替换测试 (DSST) 成绩负相关.
- 观察到非线性关系;确定ALP,AST/ALT比率,GGT和ALT的特定值,以增加或减少认知障碍风险.
结论:
- 肝酶和认知表现之间存在显著的非线性关系.
- 保持肝酶水平在最佳范围内对于减轻认知障碍风险至关重要.
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