相关实验视频
Updated: Jun 19, 2025

03:26
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
2.0K
作为一种减少在初级保健中过度活跃膀药物不适当使用的方法 (DROP) 的方法来描述抑郁症:集群随机对照试验与嵌入式解释顺序混合方法研究的协议
Ann Lykkegaard Soerensen1,2, Marie Haase Juhl1,3, Marlene Lunddal Krogh1,4
1Department of Pharmacology, Aalborg University Hospital, Aalborg, Denmark.
JMIR research protocols
|July 23, 2024
概括
这项研究调查了老年人过度活性膀 (OAB) 的抑郁抗胆固醇药物. 目标是通过混合方法方法来提高药物安全性和患者的治疗结果.
科学领域:
- 老年医学 老年医学
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 潜在的不适当的药物使用,特别是过活性膀 (OAB) 的抗胆药,是老年人 (65岁以上) 的担忧.
- 这项研究探讨了OAB的替代治疗方法,以及这些常用的抗胆固醇药物的抑郁症.
- 一种混合方法的方法将评估减记效率,患者/提供者经验以及潜在的障碍.
研究的目的:
- 评估初级保健干预措施的有效性和安全性,鼓励患者参与OAB药物处方.
- 在OAB药物处方过程中识别促进者和障碍物.
- 为基于证据的决策提供信息,并支持安全,有效的OAB治疗.
主要方法:
- 一个随机对照试验 (RCT) 与嵌入式顺序解释混合方法设计 (在初级保健中治疗过活性膀的药物 - DROP研究).
- 北丹麦地区的一般实践将被配对并随机分为干预 (算法引导的抑郁) 和对照组.
- 来自注册表的定量数据和来自患者和医疗保健专业人员的访谈/焦点小组的定性数据将被收集和合并.
主要成果:
- 目前DROP研究正在进行中,一般实践随机化正在进行中 (2023年12月 - 2024年4月).
- 患者的随访时间为6个月,使用治疗意图 (RCT) 和主题分析 (定性) 分析结果.
- 结果将包括处方,症状的变化,以及对经验和感知的定性见解.
结论:
- 该DROP研究旨在提供基于证据的干预措施,以减少OAB药物的处方,在初级保健中具有不利的风险效益概况.
- 它将产生关键的证据,对解药实践.
- 预计这些发现将影响OAB管理的医疗保健最佳实践.
相关概念视频
Drugs for Treatment of Diarrhea-Predominant IBS
156
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
156
Prescription, Nonprescription and Orphan Drugs
714
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
714
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
348
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
348
Antihypertensive Drugs: Action of Diuretics
647
Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
647
Antidepressant Drugs: MAOIs and Other Agents
209
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
209
Drug Therapy
41
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
41

