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Updated: Jun 19, 2025

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在CLL中T细胞功能障碍是通过在CLL细胞上表达Siglec-10配体CD24和CD52的介导

Jaco A C van Bruggen1,2, Fleur S Peters1,2, Morris Mes1,2

  • 1Department of Hematology, Cancer Center Amsterdam, Lymphoma and Myeloma Center Amsterdam, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Blood advances
|July 23, 2024
PubMed
概括

慢性淋巴细胞白血病 (CLL) 通过抑制T细胞功能,损害了仿真抗原受体 (CAR) T细胞疗法. 向CLL细胞表面连接体CD24和CD52可以重振T细胞,改善CLL患者的CART细胞疗效.

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