药剂师管理的口服表皮生长因子受体抑制剂的影响
Shirley Ng1, Nicholas Baker2, Fang Niu3
1Clinical Pharmacy, Kaiser Permanente Northern California, San Jose, CA, USA.
药剂师管理的护理改善了口服EGFR抑制剂的非小细胞肺癌 (NSCLC) 患者的坚持和成像率. 这导致了更好的监测和及时的治疗调整,改善了患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 临床药房 临床药房
- 药物经济学 药物经济学
背景情况:
- 药剂师在药物管理中发挥着至关重要的作用,在优化复杂口服抗癌药物的结果方面承担着越来越大的责任.
- 临床药房服务有记录的积极影响患者的结果.
研究的目的:
- 评估药剂师管理的口服化疗诊所的影响.
- 在接受口服表皮生长因子抑制剂 (EGFRi) 治疗方案的非小细胞肺癌 (NSCLC) 患者的评估结果.
主要方法:
- 观察性队列研究,将药剂师管理的护理与EGFRi治疗的NSCLC患者的常规护理进行比较 (2017-2019).
- 分析了依从性 (覆盖日数的比例),成像频率 (CT/MRI) 和成像时间相对于治疗变化.
- 使用奇方位和学生的t测试/威尔科克森等级和测试进行结果分析.
主要成果:
- 药剂师管理的护理组显示了显著更高的坚持 (PDC ≥0.80: 95.8% vs 92.4%,p=0.01) 和覆盖日数比例 (0.86 vs 0.82,p=0.01).
- 在药物暴露期间,CT/MRI成像率较高 (31.8%对20.7%,p<0.01) 并且在药剂师管理的组中观察到每个患者的扫描率较高.
- 药剂师管理组的患者在治疗更改之前更频繁地完成成像 (36.3%与26.3%,p<0.01) 扫描和更改之间的中位数时间较短 (1.8与4个月,p=0.04).
结论:
- 临床药房服务显著改善了EGFRi治疗NSCLC患者的药物坚持.
- 通过更高的成像率和及时调整治疗来加强监测与药剂师管理有关.
- 药剂师主导的干预措施优化了口服化疗患者的护理,改善了依从性和监测频率.
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