白质结构的变化与幻觉易感有关
Joseph F Johnson1, Michael Schwartze2, Michel Belyk3
1Université Libre de Bruxelles, Center for Research in Cognition & Neurosciences, Bruxelles, Belgium; University of Maastricht, Department of Neuropsychology and Psychopharmacology, Maastricht, The Netherlands.
NeuroImage. Clinical
|July 23, 2024
概括
具有较高幻觉易感 (HP) 的健康个体表现出明显的白质结构差异. 这项研究揭示了大脑变异与一般人群中精神病风险相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 幻觉是常见的精神病症状,也发生在健康的人身上.
- 在健康人群中,持续的精神病类经历可能预测未来的精神病障碍.
- 精神病连续性表明在临床和非临床人群中共享的大脑变异.
研究的目的:
- 在健康个体中调查与幻觉易感 (HP) 相关的白质结构差异.
- 探索HP和大脑结构之间的关系,绕过临床混.
- 为了确定特定的白质途径涉及到健康人口中精神病风险.
主要方法:
- 扩散张力成像 (DTI) 用于评估白质结构.
- 这项研究包括50名健康参与者 (35名女性).
- 在特定的纤维通道中,分析了与HP相关的微分异型性 (FA).
主要成果:
- 增加的HP与关键白质道中的增强的分数异构性 (FA) 相相关.
- 具体来说,右侧未切割的囊,双侧弧形囊和体显示出显著的变化.
- 这些发现提供了与健康个体中HP相关的结构白质变异性的第一个证据.
结论:
- 这项研究支持精神病连续模型,可以通过健康个体的大脑结构来检测.
- 针对性途径的结构变化可能与突出性和注意力机制有关.
- 这些发现突出了一般人群中精神病风险的潜在神经生物学标志物.
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