与非西班牙裔白人相比,西班牙裔人主观认知衰退的两年纵向结果
Carolina Boza-Calvo1,2,3, Arline Faustin3,4, Yian Zhang3,5
1Centro de Investigación en Hematología y Trastornos Afines (CIHATA), Universidad de Costa Rica, San José, Costa Rica.
Journal of geriatric psychiatry and neurology
|July 23, 2024
概括
患有主观认知衰退 (SCD) 的西班牙裔人面临更高的进展到轻度认知障碍 (MCI) 的风险. 与非西班牙裔白人相比,这种增加的风险与更多的抑郁症状和客观认知衰退有关.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 主观认知衰退 (SCD) 是痴呆症的早期阶段,在高风险的西班牙裔人口中对其理解有限.
- 西班牙裔受痴呆症的影响不成比例,需要对他们的认知健康轨迹进行研究.
研究的目的:
- 在西班牙裔与非西班牙裔白人 (NHW) 之间调查从SCD进展到轻度认知障碍 (MCI) 的风险.
- 为了比较这些群体之间的抑郁症状,SCD投诉和客观认知表现的基线和纵向特征.
主要方法:
- 一组23名西班牙裔和165名患有SCD的NHW参与者在基线和2年随访时被评估.
- 评估包括功能状态,抑郁症状,SCD和客观认知表现的测量.
主要成果:
- 西班牙裔人从SCD进展到MCI的风险明显更高 (OR:6.10,P = .040).
- 西班牙裔参与者报告了更多的基线抑郁症状 (P = .048),这些症状随着时间的推移而恶化 (OR: 3.16,P = .023).
- 在西班牙裔中,增加了SCD投诉,特别是在注意力,记忆力和功能领域.
- 客观认知测试显示西班牙裔在包括MMSE,MoCA,Trails A/B和延迟回忆在内的措施中显著下降.
结论:
- 西班牙裔种族与在两年内从SCD进展到MCI的风险大幅增加有关.
- 这种高风险与更大的抑郁症状,特定的SCD投诉以及明显的amnestic和non-amnestic认知衰退相关.
- 进一步的研究对于加强西班牙裔人口临床前痴呆症评估策略至关重要.
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