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小肠胆汁酸调节肠道微生物组,以改善减肥手术后的主体代谢表型
Yingjia Chen1, Snehal N Chaudhari2, David A Harris3
1Laboratory for Surgical and Metabolic Research, Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA.
Cell host & microbe
|July 23, 2024
概括
腹腔外科手术通过改变胆汁酸来改善2型糖尿病. 陶氧化胆酸 (TDCA) 减少有害的石化胆酸 (LCA),改善葡萄糖代谢,并可能有助于糖尿病缓解.
科学领域:
- 代谢手术是一种代谢手术.
- 我们的肠道微生物组.
- 胆汁酸代谢 胆汁酸代谢
背景情况:
- 腹腔外科手术,像袖子胃切除术 (SG),有效地诱导2型糖尿病 (T2D) 缓解.
- 在SG后观察到胃肠道 lithocholic 酸 (LCA) 水平的降低.
- 特定胆汁酸在SG后T2D缓解中的作用仍然不清楚.
研究的目的:
- 研究LCA在葡萄糖不耐受和新陈代谢中的作用.
- 为了确定影响LCA生产的受SG影响的胆酸.
- 探索TDCA作为代谢功能障碍治疗剂的潜力.
主要方法:
- 评估LCA对小鼠葡萄糖耐受性和全身新陈代谢的影响.
- 研究了 taurodeoxycholic 酸 (TDCA) 对体外和体内LCA 生产的影响.
- 向饮食诱导的肥胖小鼠服用TDCA,并分析了代谢和微生物组的变化.
- 从T2D患者的小肠组织中量化TDCA水平.
主要成果:
- 在小鼠中,LCA的使用使葡萄糖耐受性恶化和代谢受损.
- TDCA抑制了细菌胆酸诱导性 (bai) 操作子和LCA的产生.
- 在肥胖小鼠中,TDCA治疗降低了LCA水平,导致葡萄糖处理的微生物组依赖性改善.
- 在T2D患者的小肠中,TDCA水平下降.
结论:
- TDCA 作为LCA 生产的内源性抑制剂.
- TDCA可能会调解减肥手术的一些葡萄糖调节效应.
- TDCA代表了改善葡萄糖代谢和T2D的潜在治疗标.
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