我们所有人的怀孕事件:利用多来源数据进行与怀孕相关的研究
Louisa H Smith1,2, Wanjiang Wang1, Brianna Keefe-Oates1,2
1Department of Public Health and Health Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA 02115, United States.
概括
我们所有人研究计划确定了近19,000个怀孕情节,证明了其研究不同孕妇群体的潜力. 然而,人口代表性各不相同,这凸显了在怀孕研究中需要仔细评估偏见的需要.
科学领域:
- 生物医学研究生物医学研究
- 人口健康 人口健康
- 生殖健康 生殖健康
背景情况:
- 孕妇在生物医学研究中代表性不足.
- 怀孕研究受限于数据的可用性和参与者的多样性.
- 我们所有人的研究计划收集了来自不同人口的广泛健康数据.
研究的目的:
- 在我们所有人的电子健康记录 (EHR) 中识别高质量的怀孕情节.
- 评估我们所有人计划对与怀孕有关的研究的有用性.
- 评估计划内的怀孕队列的人口多样性.
主要方法:
- 利用已发表的算法来识别所有我们EHR数据中的怀孕情节.
- 描述了已识别的怀孕情况,并使用我们所有人调查数据验证了它们.
- 怀孕队列的人口统计特征与国家统计数据的比较.
主要成果:
- 从14234名参与者中确定了18970次怀孕事件.
- 验证显示,在确定的怀孕中,假阳性和假阴性率较低.
- 人口统计数据显示,与全国数据相比,老年人,受过高等教育的个人占比过高,亚裔美国人占比不足.
结论:
- 我们所有人计划有能力通过其多样化的数据支持怀孕研究.
- 确定的妊娠队列表现出人口多样性,但在某些群体中也有显著的代表性不足.
- 在使用此资源进行怀孕研究时,需要仔细考虑潜在的偏差.
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