脑下垂体-垂体-卵巢轴抑制在美国陆军基本作战训练期间在女性中很常见
Kristin L Popp1,2,3, Brittany N Bozzini4, Marinaliz Reynoso4
1Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA kpopp@mgh.harvard.edu.
British journal of sports medicine
|July 23, 2024
概括
军事训练显著抑制了服役妇女的生殖健康,即使是那些报告定期周期的妇女. 这项研究揭示了在美国陆军基本作战训练期间的深度下丘脑-垂体-卵巢轴抑制.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 军事医学 军事医学
- 妇女健康 妇女健康
背景情况:
- 服务女性自我报告的月经状况可能不准确地反映下丘脑-垂体-卵巢 (HPO) 轴抑制.
- 军事训练对妇女的生殖健康有重大影响.
- 低估HPO轴抑制可能导致忽视生殖健康问题.
研究的目的:
- 在美国陆军基本战斗训练 (BCT) 期间,对女性的HPO轴功能进行特征化.
- 在这个人群中探索对HPO轴抑制的潜在贡献者.
- 评估自我报告的月经状况与客观荷尔蒙标志物的准确性.
主要方法:
- 55名进入BCT的多民族女性的前性观察研究.
- 每日尿液和每周血液样本在10周内收集,以测量关键的生殖荷尔蒙.
- 在研究开始和结束时使用双能X射线吸收计评估的身体组成.
主要成果:
- 尽管78%的人报告BCT前有规律的周期,但只有12.5%的人在训练期间显示出排卵的迹象.
- 75%的受训者没有表现出黄素活性 (NELA) 的证据,这表明显著的HPO轴抑制.
- 身体质量和组成的变化与白色素活性没有直接关系.
结论:
- 在BCT期间,大多数女性发生了深刻的HPO轴抑制,无论报告的正常月经周期如何.
- 客观的荷尔蒙评估显示,生殖障碍的患病率高于自我报告所表明的.
- 调查结果强调,需要针对正在接受强化培训的服务女性进行有针对性的生殖健康监测.
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