帕金森病精神病与加速的多域认知衰退相关
Sara Pisani1, Luca Gosse2, Dag Aarsland3,4
1Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
BMJ mental health
|July 23, 2024
概括
与没有精神病的患者相比,患有帕金森病 (PD) 精神病的患者经历了更快的认知衰退,特别是在记忆和处理速度方面. 这突出了PD精神病影响的关键认知领域.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
背景情况:
- 帕金森病 (PD) 精神病中的认知缺陷会对生活质量产生负面影响,并增加痴呆风险.
- 在PD精神病症中认知衰退的具体轨迹尚不清楚.
研究的目的:
- 与没有精神病 (PDnP) 的患者相比,研究患有帕金森病精神病 (PDP) 的患者的纵向认知变化.
主要方法:
- 分析了来自帕金森病进展标志物倡议 (Parkinson's Progression Markers Initiative) 之前未服用过药物的PD患者 (n=676) 和健康对照组 (HC,n=187) 的5年数据.
- 根据精神病症状将PD患者分为PDP和PDnP组.
- 使用线性混合效应模型,控制社会人口统计学,抑郁症,嗜睡,REM睡眠行为障碍和运动症状.
主要成果:
- 在PD患者组 (PDP与PDnP) 之间没有观察到基线认知差异.
- 与PDnP患者相比,患有PD精神病 (PDP) 的患者在5年内在多个领域 (包括记忆,全球认知,视觉空间功能,语义流性和处理速度) 显示出显著更大的认知衰退.
- 即使控制了各种混因素后,这些下降仍然存在.
结论:
- 帕金森病精神病与语义语言,处理速度,全球认知,视觉空间能力和记忆的显著下降有关.
- 这些认知领域,特别是语义语言,在PD精神病中至关重要,需要进一步研究.
关键词:
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