开发,优化和评估用于治疗H.Pylori的阿莫西西林粘膜微球,通过全工厂设计
Bhawna Sharma1, Anand Chaurasia1, Naveen Gupta1
1Patel College of Pharmacy, Madhyanchal Professional University, Ratibad, Bhopal, MP. India.
概括
含有阿莫西西林的粘膜粘合微球被开发用于H. pylori治疗. 优化的配方显示出良好的粘膜粘附性,高药物捕获和持续释放,改善治疗结果.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 微生物学 微生物学
背景情况:
- 氨基西林对于根除H. pylori至关重要,但需要有效的输送.
- 药物半衰期短,需要制定持续治疗水平的策略.
- 粘膜粘合系统在胃肠道中提供了长时间的停留时间.
研究的目的:
- 制定和评估含有阿莫西西林的粘膜粘合微球.
- 为了研究持续的药物释放以改善H. pylori治疗.
- 优化微球特性,以提高口服生物利用性.
主要方法:
- 使用乳化-交叉连接与瓜尔,酸和奇托制备的微球.
- 阿莫西西林被纳入了奇托溶液.
- 特性包括颗粒大小,粘膜粘合,药物捕获和体外释放研究.
主要成果:
- 微球颗粒大小在200-500微米之间.
- 优化的配方 (F-9) 显示了57.41%的粘膜粘合和94.87%的药物捕获.
- 在8小时内实现了68.52%的持续药物释放.
结论:
- 开发出的阿莫西西林微球在GIT中提供持续释放.
- 这种配方可以长时间保持稳定的血清药物度.
- 粘膜粘合微球为H.pylori治疗提供了一个有前途的方法.
相关概念视频
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The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
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The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
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