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与代谢功能障碍相关的脂肪性肝病患者的白细胞端粒长度

Debora Goncalves da Silva¹, Nadyellem Graciano da Silva², Angelica Amorim Amato²

¹University Center Atenas Paracatu, Avenida Euridamas Avelino de Barros, 60, Paracatu, Minas Gerais 38600-000, Brazil; Laboratory of Molecular Pharmacology, Department of Pharmaceutical Sciences, Campus Universitario Darcy Ribeiro, Brasilia, Distrito Federal 70910-900 Brazil.

Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

|July 23, 2024

概括

年龄是与代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的端粒长度相关的主要因素. 这项研究发现年龄,而不是端粒长度,显著影响了MASLD指标.

科学领域:

肝病学肝病学是一种肝病学.
代谢健康代谢健康
遗传学遗传学是一个

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
外围白细胞端粒长度 (TL) 是细胞衰老的生物标志物.
需要进一步研究TL和MASLD代谢指标之间的关系.

研究的目的:

调查外围白细胞端粒长度与MASLD患者的代谢异常之间的联系.
评估磁共振成像 (MRI) 在评估肝脏脂肪分数 (HFF) 中的作用.

主要方法:

对成年人 (>20年,BMI>25 kg/m2) 具有超声波确认的肝肥胖症的横截面研究.
评估包括临床/生化变量,MRI确定的HFF和对相对外围白细胞端粒长度 (T/S比) 的定量实时PCR.

主要成果:

分析了32名MASLD受试者 (平均年龄40岁,中位数BMI为33.75,中位数HFF为19%).
较低的端粒长度 (T/S比低于中位数) 与较高的年龄,较低的BMI,较高的AST/GGT,较低的费里丁和较高的FIB4得分相关.
多变量分析确定年龄是MASLD中与端粒长度相关的唯一显著因素.

结论:

年龄是MASLD患者端粒长度的最重要的决定因素.
在这个特定的患者群体中,端粒长度可能不是代谢功能障碍的主要指标.

关键词:

细胞衰老细胞衰老马斯尔德马斯尔德是什么意思端粒长度端粒长度端粒长度端粒是什么意思端粒是什么意思

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