代谢生物标志物和高血压中的心血管风险分层
D Piskorz1, L Keller1, L Citta1
1Cardiology Institute of the Rosario British Sanatorium, Rosario, Argentina.
Hipertension y riesgo vascular
|July 23, 2024
概括
高甘油三糖指数 (TyGi) 是胰岛素抵抗的标志物,与高血压患者心血管风险增加有关. TyGi与其他胰岛素抵抗生物标志物相关,这表明它对风险分层的临床实用性.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 预防医学 预防医学
背景情况:
- 心血管风险计算器 (CRC) 缺乏当地验证.
- 胰岛素抵抗的替代生物标志物可以识别2型糖尿病和心血管疾病 (CVD) 风险较高的人.
研究的目的:
- 为了确定胰岛素耐药性患病率,替代生物标志物.
- 评估这些生物标志物与非糖尿病高血压患者接受初级预防的CRC之间的相关性.
主要方法:
- 有潜在连续门诊患者的观察注册表.
- 甘油三糖指数 (TyG指数) 的计算:Ln (禁食甘油三糖 × 禁食血葡萄糖 / 2).
- 根据TyG指数四分位数进行分层,并评估皮尔森相关系数.
主要成果:
- 该研究包括406名高血压患者 (56.9%是男性,平均年龄为55.9岁).
- 更高的TyG指数四分位数与增加的ASCVD风险 (p=0.02) 和更高频率的AHA/ACC聚合队列方程风险相关 >7.5% (p<0.005).
- 在TyG指数和TG/HDL比率 (r=0.7076,p<0.0001) 和非HDL胆固醇 (r=0.4553,p<0.0001) 之间发现了显著的相关性.
结论:
- 患有TyG指数升高的非糖尿病高血压患者表现出更高的10年心血管风险.
- 泰格指数是胰岛素耐药性的可靠替代生物标志物,与其他代谢生物标志物有显著的相关性.
- 在临床实践中,TyG指数可以作为心血管风险分层的宝贵工具.
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