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Updated: Jun 19, 2025

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
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Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

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根据HLA-DR4呈现的T细胞对素化表位体的特异性的分子基础

Tiing Jen Loh1, Jia Jia Lim1, Claerwen M Jones1

  • 1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Australia.

Nature communications
|July 23, 2024
PubMed
概括

在类风湿性关节炎 (RA) 中,T细胞受体 (TCR) 基因的使用与素化表位相关. 这项研究揭示了特定的TCR基因偏差和结构相互作用,澄清了TCR特异性的分子机制.

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In Situ Detection of Autoreactive CD4 T Cells in Brain and Heart Using Major Histocompatibility Complex Class II Dextramers13:10

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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