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对SARS-CoV-2类似帕帕因蛋白酶的突变分析揭示了对功能,结构和药物逃脱的要求

Xinyu Wu1,2, Margareta Go1, Julie V Nguyen1

  • 1The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

Nature communications
|July 23, 2024
PubMed
概括

深度突变扫描揭示了突变如何影响SARS-CoV-2类似帕帕因蛋白酶 (PLpro) 的活性和稳定性. 了解这些变化有助于设计有效的抗病毒药物和克服耐药性.

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