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Updated: Jun 19, 2025

Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
08:01

Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice

Published on: May 16, 2021

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达帕格利弗洛辛通过SIRT1激活来改善骨肌肉的胰岛素敏感性,这种激活是由营养缺乏状态引起的

Qi Gao1, Yingying Jiang1, Zhenqiang Song1

  • 1NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, 300134, China.

Scientific reports
|July 23, 2024
PubMed
概括

达帕格利弗洛辛通过模仿营养缺乏,激活Sirtuin-1 (SIRT1) 来增强骨肌肉对胰岛素的敏感性. 这改善了线粒体功能和葡萄糖利用,提供了一个新的低血糖机制.

关键词:
胰岛素耐药性 胰岛素耐药性是一种在营养缺乏状态下.这是一种SGLT2抑制剂.一个SIRT1系统.骨架肌肉是一个骨肌肉.

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