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循环白细胞特征和长时间的夜班:基于广西护士的横截面研究

Zhenkun Tang¹, Yuanfang Liu², Yiyi Cheng³

¹Information Center, The Second Nanning People's Hospital, Nanning, 530031, Guangxi Zhuang Autonomous Region, People's Republic of China.

Scientific reports

|July 23, 2024

概括

护士长时间的夜班与异常的白细胞 (WBC) 计数和升高的红细胞分布宽度 (ELR) 有关. 这些发现表明轮班工作,免疫细胞变化和潜在的健康风险 (如COVID-19和癌症) 之间存在联系.

科学领域:

免疫学免疫学免疫学
职业健康职业健康职业健康
时间生物学时间生物学

背景情况:

轮班工作,特别是夜班,在护士中很普遍.
由于轮班工作而导致昼夜节律的扰乱,可能会影响生理过程.
了解夜班的免疫后果对于医疗保健工作者福祉至关重要.

研究的目的:

研究长期夜间和白天轮班工作对护士免疫细胞参数的影响.
为了确定与夜班工作相关的特定外周血液指标.
探索轮班工作,免疫标志物和潜在的健康风险之间的关系.

主要方法:

一项涉及1568名健康护士的横截面研究,其中1093人从事长期轮班工作 (>1年).
统计分析包括接收器操作特征 (ROC) 曲线,集体学习 (使用LASSO) 和后勤回归.
评估各种全血细胞计数参数,包括白细胞计数和红细胞长度比 (ELR).

主要成果:

与日班工作者相比,夜班工作的护士表现出明显更高的白细胞 (WBC) 计数和改变的红细胞长度比率 (ELR).
在ROC曲线分析中,WBC,ELR和其他参数被确定为夜班工作的重要指标.
后勤回归证实,夜班显著影响了ELR和WBC水平,根据护士长度的影响有所不同.

结论:

长时间的夜班工作与护士的WBC和ELR的显著变化有关.
这些免疫细胞的变化可能会导致与昼夜节律扰乱相关的健康问题,例如对感染 (例如COVID-19) 和瘤发生的易感性增加.
需要进一步的研究,以充分阐明轮班工作引起的免疫失调对长期健康的影响.

关键词:

循环节律是循环节律的节奏.氨基酸与淋巴细胞的比率.护士是一个护士.轮班工作轮班工作在WBC中,WBC就是WBC.

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