在新生儿BCG疫苗接种和气溶BCG再接种后, rhesus的免疫细胞群动态
Laura Sibley1, Charlotte Sarfas1, Alexandra L Morrison1
1UK Health Security Agency, Porton Down, Salisbury, SP4 0JG, UK.
Scientific reports
|July 23, 2024
概括
婴儿的BCG疫苗接种并没有改变免疫细胞的发育,但引起了短期的抗原特异性反应. 成年后的长期再接种疫苗显示出受过训练的先天免疫力的潜力,影响未来的免疫反应.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 随着时间的推移,Bacille Calmette-Guérin (BCG) 疫苗的有效性逐渐减弱.
- 婴儿和成人免疫系统不同,可能会影响疫苗的有效性.
研究的目的:
- 研究早期BCG疫苗接种对婴儿 rhesus macaques免疫细胞群的影响.
- 评估婴儿BCG疫苗接种对成人再接种疫苗的免疫反应的长期影响.
主要方法:
- 34只婴儿 rhesus 被BCG疫苗接种,并被监测了88周.
- 分析血液样本以检测免疫细胞群变化.
- 一项试点研究涉及BCG再接种在以前作为婴儿接种疫苗的成年.
主要成果:
- 接种BCG疫苗并没有显著改变免疫细胞组成或扰乱婴儿的正常发育.
- 与成人相比,婴儿表现出较高的CD4+T细胞,Tregs和NK细胞.
- 在接种疫苗后36周内,婴儿的抗原特异IFNγ反应可以检测到.
- 成年人重新接种疫苗诱导了PPD特定的IFNγ和细胞因子分泌量的增加,这表明受过训练的先天免疫力.
结论:
- 在的早期生活中BCG接种疫苗是安全的,不会破坏免疫发育.
- 婴儿BCG疫苗接种诱导了短暂的抗原特异性免疫力.
- 婴儿BCG疫苗接种可能会使免疫系统在以后的再接种时获得增强的反应,这表明受过训练的先天免疫力.
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