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产前暴露于酸 (Benzo[a]pyrene) 通过胎盘亡 (placental apoptosis) 影响着母亲和胎儿之间的关系

Nan Zhao¹, Jun Chu², Jieying Liu³

¹Institute of Clinical Medicine, National Infrastructures for Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, #1 Shuaifuyuan, Dongcheng Dist., Beijing, 100730, China. nanzhao_2016@foxmail.com.

Scientific reports

|July 23, 2024

概括

产前暴露于 (Benzo[a]pyrene (BaP)) 增加了早产风险,并损害了母亲和胎儿的结果. 高剂量的BaP会诱导胎盘亡并改变基因表达,在动物模型和人类研究中影响怀孕.

科学领域:

环境毒理学环境毒理学
生殖生物学生殖生物学
发展性毒理学发展性毒理学

背景情况:

产前暴露于 (Benzo[a]pyrene (BaP) 与不良妊娠结果有关.
在BaP的生殖毒性中,特定的机制,特别是胎盘亡,仍然不清楚.

研究的目的:

调查胎盘亡在[a]皮林 (BaP) 诱导的生殖毒性的作用.
为了检查产前BaP暴露对动物模型和人类种群的母胎结局的影响.

主要方法:

母体动物模型使用野生类型和p53异性淘汰小鼠暴露于不同剂量的BaP.
嵌套病例控制研究分析了83名患有PB和82名到期分娩的妇女的产前BaP暴露和早产 (PB).
评估了胎盘亡,p53,Bax/Bcl-2表达,以及MMP2水平.

主要成果:

高剂量的BaP暴露增加了小鼠的早产发病率,胎儿死亡和再吸收.
观察到显著的剂量依赖性减轻母亲和出生体重,并增加胎盘体重.
较高的p53-介导的胎盘亡和改变的p53/Bax/Bcl-2表达被发现与更高的BaP剂量.
在高BAP暴露的妇女中,MMP2表达量的增加与早产风险的增加有关.

结论:

在怀孕期间暴露于[a]pyrene (BaP) 诱导生殖毒性和不利的母胎后果.
暴露于BaP会触发p53-介导的胎盘亡,导致毒性.
来自动物模型的发现转化为人类种群,突出显示BaP是早产风险因素.

关键词:

孕产妇和胎儿的不良后果子[a]二烯是一种二烯.矩阵金属蛋白酶是一种金属蛋白酶.胎盘细胞亡是胎盘细胞亡.产前暴露在产前暴露.

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