耐火性慢性集群头痛的个人资料
Javier A Membrilla1, María-Luz Cuadrado2,3, Nuria González-García2
1Neurology Department, Hospital Universitari Francesc de Borja, Avinguda de la Medicina, 6, Gandia, 46702, València, Spain. membrilla_jav@gva.es.
概括
超过一半的慢性集群头痛患者经历了耐火性症状,往往诊断延迟和治疗成功有限. 性毒素A和部神经刺激显示出治疗耐火性慢性集群头痛的潜力.
科学领域:
- 神经学 神经学
- 头痛 医学 医学 医学
背景情况:
- 慢性集群头痛 (CCH) 是一种罕见的,具有挑战性的初级头痛疾病.
- 耐火性CCH (rCCH) 的患病率和特征尚未得到很好的定义.
研究的目的:
- 为了确定一个CCH群体中rCCH的频率.
- 确定耐火患者使用的临床形状和治疗方法.
主要方法:
- 在西班牙马德里的88名CCH患者的横截面研究.西班牙马德里.
- 收集关于人口统计,临床表现和治疗的数据.
- 根据欧洲头痛联合会的标准定义的rCCH;高疾病活性定义为>=3次严重发作/周,尽管接受治疗,但影响生活质量.
主要成果:
- 68.2%的CCH患者符合rCCH标准.
- rCCH患者的诊断延迟时间较长 (4.6年对3.2年).
- 使用了无毒毒素A和尾神经刺激 (ONS),其中止率很高;50%的ONS仍然活跃. 尽管接受了治疗,但60.2%的患者患有高发病率.
结论:
- CCH往往预后不好,超过一半的患者符合折射性标准.
- 在耐火性CCH患者中,onabotulinumtoxinA和ONS可能是有效的治疗方法.
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