Nur77通过激活粒和抑制亡,改善生殖老化小鼠的卵巢功能
Ying Yao1, Bin Wang2,3, Kaihua Yu1
1The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Reproductive biology and endocrinology : RB&E
|July 23, 2024
概括
神经生长因子诱导基因B (Nur77) 激活通过促进细胞和减少老年小鼠的亡来增强卵巢储备. 这一发现为生殖衰老提供了潜在的治疗点.
科学领域:
- 生殖生物学 生殖生物学
- 老年学是一门学科.
- 细胞衰老 细胞衰老
背景情况:
- 生殖衰老加速了系统衰老,并与线粒体功能障碍,氧化还原失衡和胚胎细胞亡有关.
- 自,特别是线粒,是长寿的关键机制,但其在卵巢衰老中的作用尚不清楚.
- 神经生长因子诱导基因B (Nur77) 与年龄相关的疾病有关,但其在卵巢衰老中的作用尚未研究.
研究的目的:
- 研究Nur77在卵巢衰老中的作用及其作为治疗点的潜力.
- 阐明Nur77通过哪些机制影响卵巢功能,包括细胞化,氧化应激和亡.
主要方法:
- 鉴定Nur77作为生殖细胞衰老,细胞亡和线粒细胞衰变的调节者.
- 在老年小鼠卵巢中,Nur77的过度表达.
- 使用字符串和分子对接,分析Nur77和AKT通路之间的关联.
- 实验证实了AKT/mTOR信号通路的参与.
主要成果:
- 过度表达Nur77激活了线粒,改善了氧化应激,并在老鼠卵巢中减少了亡.
- 发现Nur77与AKT通路有关.
- AKT/mTOR信号通路调节了Nur77在卵巢功能中的作用.
结论:
- Nur77作为生殖细胞衰老,细胞亡和线粒细胞衰老的调节者.
- 通过减轻氧化应激和亡,Nur77过度表达增强了老年小鼠的卵巢储备.
- 通过AKT/mTOR通路,Nur77是与生殖衰老相关的卵巢功能下降的有希望的治疗标.
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