药用大麻茶含有可变剂量的大麻素,没有烯
Marie Bach Sønderskov1,2, Jørgen Bo Hasselstrøm3, Rime Bahij4
1Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus N, Denmark.
Basic & clinical pharmacology & toxicology
|July 23, 2024
概括
在丹麦调查大麻茶时,发现四大麻 (THC) 和大麻 (CBD) 剂量存在显著的变化. 即使在同一产品内,剂量也存在差异,这凸显了在使用大麻用于医疗目的时需要谨慎.
科学领域:
- 药理学 药理学是指药理学的学科.
- 大麻科学 大麻科学
- 分析化学 分析化学
背景情况:
- 茶是一种常见的方法,用于管理大麻处方在丹麦.
- 了解大麻茶中的精确大麻素含量对于安全有效的剂量至关重要.
- 以前的研究还没有完全阐明大麻茶制品中大麻素和类剂量的变化.
研究的目的:
- 量化四大麻醇 (THC),四大麻酸 (THCA),大麻 (CBD),大麻酸 (CBDA) 和不同大麻茶中的烯度.
- 为了确定每份大麻茶所提供的THC和CBD的实际剂量.
- 评估添加剂 (如奶油) 对大麻茶中的大麻素度的影响.
主要方法:
- 在三种复制茶制品和植物原料中分析大麻素 (THC,THCA,CBD,CBDA) 和类度.
- 使用分析化学技术进行量化.
- 基于标准份量 (0.2L) 的THC和CBD剂量的计算.
主要成果:
- 标准茶中的THC度根据产品标签有显著差异,从9.5至36μg/mL不等.
- 8%标签产品中的茶中的CBD度为7.5μg/mL.
- 每0.2升份的实际剂量在0.46至11.3毫克THC和0.38至2.0毫克CBD之间.
- 在煮沸之前添加奶油会使THC和CBD度分别增加2.3-4.4倍和2.1倍.
- 在植物物质中检测到烯,但在准备好的茶中没有.
结论:
- 大麻茶制品在THC和CBD剂量上表现出相当大的变化,即使使用相同的产品.
- 制备方法,包括添加奶油,可以显著改变大麻素的生物可用性.
- 这些发现对于临床医生来指导产品选择和患者来了解大麻茶的潜在剂量变化至关重要.
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