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Updated: Jun 19, 2025

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
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Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

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通过粗粒度模拟和无监督学习来探索DNA的蛋白质介导紧缩

Marjolein de Jager1, Pauline J Kolbeck2, Willem Vanderlinden3

  • 1Soft Condensed Matter and Biophysics, Debye Institute for Nanomaterials Science, Utrecht University, Utrecht, the Netherlands.

Biophysical journal
|July 24, 2024
PubMed
概括

蛋白质与蛋白质的相互作用对DNA紧缩至关重要,推动循环结构的形成. 这项研究引入了一个粗的模型和机器学习方法来分析这些复杂的生物过程.

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