抵抗运动对阿尔茨海默病动物模型认知功能的有效性:系统性审查和元分析
F O de Andrade Santos1, A A Passos, R M Arida
1Ricardo Mario Arida, Physiology Department, Federal University of São Paulo, SP, Brazil, arida@unifesp.br.
The journal of prevention of Alzheimer's disease
|July 24, 2024
概括
抵抗运动 (RE) 在阿尔茨海默氏症 (AD) 动物模型中改善记忆的承诺. 这种疗法可能提供一种预防认知衰退的保护策略,尽管需要更多的研究.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 运动生理学 运动生理学
背景情况:
- 阿尔茨海默病 (AD) 是导致痴呆的主要原因,需要探索替代治疗策略.
- 包括抵抗运动 (RE) 在内的补充疗法正在研究它们在治疗AD方面的潜力.
- 了解RE在AD模型中对认知功能的影响对于开发有效干预措施至关重要.
研究的目的:
- 在阿尔茨海默病 (AD) 动物模型中系统地审查和元分析抗力运动 (RE) 对认知功能的影响.
- 调查与RE对AD影响相关的潜在生理机制.
- 评估RE作为AD治疗和预防认知衰退的补充疗法的潜力.
主要方法:
- 一个遵循PRISMA指南的系统审查和元分析,在PROSPERO注册 (CRD42019131266).
- 在四个主要数据库中进行的搜索:MEDLINE/PUBMED,SCOPUS,Web of Science和谷歌学者.
- 使用SYRCLE和CAMAREDES评估偏差风险和方法质量;使用随机效应模型计算95%置信区间的标准化平均差异.
主要成果:
- 在选了1,807个初始记录后,包括了11项研究;8项研究用于元分析.
- 抵抗运动 (RE) 在阿尔茨海默病 (AD) 动物模型中对记忆产生了积极影响.
- 在研究的AD动物模型中,没有观察到RE对焦虑水平的显著影响.
结论:
- 抵抗运动 (RE) 进行4-6周,每周超过三次,显著保护记忆功能.
- 包含的研究表现出高偏差风险和中等的方法质量,这表明有局限性.
- 在阿尔茨海默氏病 (AD) 的临床前模型中,RE成为预防认知衰退的潜在策略.
更多相关视频
09:45Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
Published on: March 22, 2016
10.2K
10:19Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
Published on: August 22, 2014
14.2K
相关概念视频
Alzheimer's Disease: Treatment
172
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
172
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
114
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
114
Alzheimer's Disease: Overview
456
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
456
