生物标志物和认知研究,新加坡 (BIOCIS):协议,研究设计和初步发现
Y J Leow1, J D J Wang, A Vipin
1Associate Professor Nagaendran Kandiah, Lee Kong Chian School of Medicine - Imperial College London, Nanyang Technological University, 11 Mandalay Rd, Singapore 308232, Nagaendran_Kandiah@ntu.edu.sg.
The journal of prevention of Alzheimer's disease
|July 24, 2024
概括
这项研究调查了不同东南亚人口中的痴呆症生物标志物. 这些发现可能会改善早期发现和预防阿尔茨海默病和认知障碍的预防策略.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 专注于预防医学和早期发现痴呆症.
- 阿尔茨海默病 (AD) 的生物标志物在症状出现几十年前就出现了.
- 亚洲人群认知疾病的有限研究.
研究的目的:
- 在东南亚人认知障碍 (CI) 的病理生物学特征.
- 使用生物标志物,神经成像和临床结果的纵向研究.
- 在多民族人口中调查痴呆症.
主要方法:
- 在新加坡进行了为期5年的纵向研究 (BIOCIS).
- 招募2500名参与者 (30-95岁).
- 评估包括神经成像,液体生物标志物,认知测试,生活方式,视网膜扫描和微生物组.
主要成果:
- 共有1148名参与者 (中国人,印度人,马来人).
- 平均年龄61.32岁,14.34岁的教育程度.
- 大脑小血管疾病的患病率为90.2%.
结论:
- 确定亚洲人痴呆症的新生物标志物和病理轨迹.
- 告知风险分层和精确医学,以预防阿尔茨海默病.
- 通过公共卫生保健洞察力改善患者结果的潜力.
相关概念视频
01:24iChip
The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
01:17Microbial Biosensors
Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...