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突破伤口关闭的界限:一种新的聚氨组织粘合剂,具有增强的愈合特性

Qiangqiang Zhou^1,2, Zhaocheng Shi^2,3, Liyao Xia⁴

¹Department of Operative Dentistry and Endodontics, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China.

Journal of biomedical materials research. Part A

|July 24, 2024

概括

研究人员开发了一种新的聚氨组织粘合剂,使用了用SiO2纳米粒子增强的L-lysine diisocyanate (LDI) 和trimethylolpropane (TMP). 这种生物相容的粘合剂显示出优越的强度,并促进伤口愈合,为 sutures 提供了一个有希望的替代品.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
手术创新在外科创新.

背景情况:

传统的和具在伤口关闭方面存在局限性.
现有的组织粘合剂在生物相容性,生物降解性和强度方面面临挑战.
需要具有更好的性能的先进的伤口封闭材料.

研究的目的:

开发一种新的生物相容聚氨组织粘合剂.
使用SiO2纳米颗粒来提高粘合强度.
评估新粘合剂的性能和生物相容性.

主要方法:

从L-lysine diisocyanate (LDI) 和trimethylolpropane (TMP) 中合成了一种新的生物相容聚氨预聚合物 (TMP-LDI).
将SiO2纳米颗粒纳入TMP-LDI预聚合物中,以产生SiO2/TMP-LDI.
评估粘合强度,固化性能,降解,生物相容性 (体外和体内),静血,抗菌活性和促进伤口愈合.

主要成果:

由于"纳米桥接效应",SiO2/TMP-LDI的粘合强度达到170.4kPa.
在固化和降解性能过程中证明了令人满意的温度变化.
具有良好的生物相容性,高效的血液静止,抗菌性质,并促进了体外和体外的伤口愈合.

结论:

SiO2/TMP-LDI是一种新型,高性能生物相容的聚氨组织粘合剂.
加入SiO2纳米颗粒显著提高了粘合强度.
开发的粘合剂显示出作为传统伤口关闭方法的优越替代品的潜力.

关键词:

它是一种抗菌药物,具有抗菌作用.生物相容性生物相容性血液静止血液静止血液静止聚氨是一种聚氨.组织粘合剂组织粘合剂伤口闭合伤口闭合

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