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金纳米集群:用于X射线激活化疗的光电转换器

Fangman Chen¹, Feixia Ruan², Xiaochun Xie²

¹State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China.

Advanced materials (Deerfield Beach, Fla.)

|July 24, 2024

概括

这项研究介绍了X射线激活化疗的新型金纳米集群策略. 它可以在深层组织中准确地释放原药,提高癌症治疗的有效性和安全性.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

在化学疗法的深层组织中开发空间时间可控的前药激活是具有挑战性的.
目前的化疗和放射治疗组合疗法缺乏精确控制瘤部位的药物释放.

研究的目的:

提出一种基于金纳米集群的金纳米集群战略的概念证明,用于X射线触发的前药物激活.
为了使放射治疗导向化疗具有增强的抗瘤疗效和安全性.

主要方法:

在X射线照射时利用金纳米集群触发 (Pt) 基前药物结合物的释放.
通过从激发状态金纳米集群到Pt(IV) 中心的直接光电子转移对前药物激活的机制进行了研究,释放了细胞毒性Pt(II) 剂.

主要成果:

与传统的化学疗法和放射疗法相比,已证明具有更高的抗瘤疗效和安全益处.
通过受控的前药激活,在瘤部位实现了时空协同作用.
诱发了强大的免疫细胞死亡,并显示了乳腺癌联合免疫治疗的深刻结果.

结论:

拟议的放射治疗导向化疗策略为控制药物输送提供了一个新的范式.
这种多功能方法能够精确调节生物过程,开启了辐射介导化学的新时代.
该策略在晚期癌症治疗和免疫治疗方面具有显著的前景.

关键词:

化疗化疗是一种化学疗法.电子转移是电子的转移.黄金纳米集群黄金纳米集群前药物激活的前药物激活辐射辐射辐射辐射的辐射

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