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在不孕治疗后怀孕的女性中产前和产后抑郁症:一项纵向研究

Yuka Ito¹, Daisuke Nishi¹

¹Department of Mental Health, Graduate School of Medicine, the University of Tokyo, Tokyo , Japan.

Journal of reproductive and infant psychology

|July 24, 2024

概括

不孕症治疗没有增加被诊断为围产期抑郁症的风险. 然而,使用不孕症治疗的女性经历了更多的产后抑郁症状,表明需要持续监测.

科学领域:

生殖健康生殖健康
心理健康心理健康
围产期护理围产期护理

背景情况:

之前关于不孕症治疗和围产期抑郁症的研究受到横截面设计和缺乏诊断工具的限制.
了解不孕症治疗对母亲心理健康的纵向影响至关重要.

研究的目的:

纵向调查不孕症治疗史和围产期抑郁症之间的关联.
为了利用经过验证的诊断工具,WHO-综合国际诊断访谈3.0 (WHO-CIDI 3.0) 和爱丁堡产后抑郁症量表 (EPDS).

主要方法:

分析了一组来自随机对照试验的对照组的2,435名孕妇队列.
生存分析评估了重大抑郁症发作的风险 (WHO-CIDI 3.0).
一般化混合模型分析检查了EPDS在四个时间点 (怀孕和产后) 的得分.

主要成果:

通过不孕症治疗怀孕的女性和自发怀孕的女性之间,重大抑郁症发作风险没有显著差异 (aHR=1.64,p=0.109).
与自发受孕相比,女性通过不孕症治疗怀孕的EPDS分数在分娩后 (1周和3个月) 显著增加.
经调整后的估计显示,从基线到产后1周 (1.17,p<0.01) 和从基线到产后3个月 (0.71,p=0.022) 的抑郁症状显著增加.

结论:

不孕不育治疗史并没有提高可诊断的围产期抑郁症的风险.
患有不孕症治疗史与子临床产后抑郁症状的边际增加有关.
对于有不孕症治疗史的女性,建议对产后抑郁症状进行长度监测.

关键词:

不孕不育不孕不育不孕不育产前抑郁症产前抑郁症孩子的出生,就是分娩.心理健康心理健康产后抑郁症产后抑郁症

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