焦虑对所有原因痴呆症的影响:来自猎人社区研究的纵向分析
Kay Khaing1, Xenia Dolja-Gore2, Balakrishnan R Nair3
1University of Newcastle, New Lambton Heights, Australia.
Journal of the American Geriatrics Society
|July 24, 2024
概括
慢性和新出现的焦虑会增加痴呆风险,特别是在70岁以下的人群中. 然而,解决焦虑症可能会降低痴呆症风险. 管理焦虑可能是预防的关键.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 焦虑是一种普遍的疾病,与痴呆症和慢性痴呆症的联系在很大程度上尚未被探索.
- 了解焦虑对痴呆风险的长期影响对于公共卫生至关重要.
研究的目的:
- 调查慢性,已解决和新出现的焦虑与所有原因痴呆症风险之间的纵向关系.
- 评估焦虑慢性如何影响随时间推移痴呆症的发展.
主要方法:
- 利用了猎人社区研究中2,132名参与者的数据 (平均年龄为76岁).
- 使用凯斯勒心理困扰尺度 (K10) 测量焦虑和通过ICD-10代码测量痴呆症.
- 采用细灰分发危险模型来分析痴呆风险,将死亡率作为竞争风险.
主要成果:
- 慢性焦虑 (HR 2.80) 和新发性焦虑 (HR 3.20) 在10年期间与所有原因痴呆风险的增加显著相关.
- 解决焦虑症没有显示出与痴呆风险的显著关联.
- 慢性/新出现的焦虑与痴呆风险之间的关联在70岁及以下的个体中尤为明显.
结论:
- 持久和新发展的焦虑与所有原因痴呆的更高风险有关,特别是在年轻人 (≤70岁) 中.
- 随着时间的推移而消失的焦虑似乎可以减轻这种增加的风险.
- 积极的焦虑管理策略可能是减少痴呆风险的潜在途径.
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