中枢神经系统预防新诊断的分散型大B细胞淋巴瘤患者在大型社区卫生系统中的利用
Michael J Williams1,2, Sol D Atienza1,2, Renee H Aranda1,2
1Department of Pharmacy Services, Aurora St. Luke's Medical Center, Advocate Health, Milwaukee, WI.
Journal of patient-centered research and reviews
|July 24, 2024
概括
中枢神经系统 (CNS) 对扩散性大B细胞淋巴瘤 (DLBCL) 的预防尚未得到充分利用. 这项研究发现,中枢神经系统预防和中枢神经系统国际预后指数 (IPI) 文档的使用率较低,复发率与现有文献相似.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床试验 临床试验
背景情况:
- 中枢神经系统 (CNS) 预防在扩散性大B细胞淋巴瘤 (DLBCL) 的作用仍在争论中.
- 中枢神经系统国际预后指数 (IPI) 有助于识别中枢神经系统复发高风险患者.
- 在指导预防决策时,CNS-IPI的现实应用尚未得到充分理解.
研究的目的:
- 在DLBCL患者群体中研究中枢神经系统预防的利用.
- 评估临床实践中中枢神经系统-IPI评分的文档和使用情况.
- 评估中枢神经系统预防对中枢神经系统疾病进展和生存的影响.
主要方法:
- 对新诊断的DLBCL患者 (2014-2017年) 的回顾性评估.
- 评估中枢神经系统的预防接收 (内化疗,高剂量IV甲状腺素).
- 对相关患者群体的中枢神经系统-IPI分数的计算;五年结果分析.
主要成果:
- 在234名患者中,只有8.6%的患者接受了中枢神经系统预防治疗 (主要是内甲状腺素).
- 在内治疗组中没有发生中枢神经系统疾病;在IV甲状腺素治疗组中,有2/8的中枢神经系统受影响.
- 中枢神经系统进展的发病率为3.7% (没有预防) 和10% (预防).
结论:
- 在社区医院系统中观察到中枢神经系统预防和中枢神经系统-IPI文档的低利用率.
- 中枢神经系统预防的有效性声明不能由于群体差异;中枢神经系统复发率与文献一致.
- 继续评估当前的中枢神经系统预防策略是合理的,需要新的,有效的疗法.
相关概念视频
Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...


