在子宫内膜异位症中体外受精后的生殖结果 - 关键因素和影响
Elena-Silvia Nadă1,2, Ciprian Andrei Coroleucă1,2, Cătălin Bogdan Coroleucă2
1Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Journal of medicine and life
|July 24, 2024
概括
这项研究发现,经过体外受精 (IVF) 的子宫内膜异位症妇女的怀孕率低于管道阻塞的妇女. 然而,使用alfa corifollitropin并考虑抗穆勒尔激素 (AMH) 和年龄改善了结果.
科学领域:
- 生殖医学 生殖医学
- 妇科 妇科 妇科 妇科
- 不孕症研究 不孕症研究
背景情况:
- 子宫内膜异位症显著影响妇女的生活质量和生育能力.
- 它通过低卵巢储备,盆腔解剖学扭曲和影响卵细胞和胚胎质量的炎症导致不孕.
- 体外受精 (IVF) 是治疗子宫内膜异位症相关不孕症的关键方法.
研究的目的:
- 将子宫内膜异位症妇女的IVF生殖结果与管道阻塞妇女进行比较.
- 确定影响子宫内膜异位症患者接受试管婴儿怀孕率的因素.
- 具体研究年龄的影响,抗穆勒尔激素 (AMH),刺激协议和淋巴激素.
主要方法:
- 175名子宫内膜异位症患者和189名输卵管阻塞患者接受试管婴儿的回顾性研究 (2019年1月至2023年12月).
- 临床怀孕率,年龄,AMH水平,刺激方案和淋巴激素类型的比较.
- 统计分析以确定影响生殖结果的独立因素.
主要成果:
- 与输卵管阻塞组 (2.55 ng/mL) 相比,子宫内膜异位症组的平均年龄相似,但平均AMH较低 (1.63 ng/mL).
- 临床怀孕率为子宫内膜异位症的27.2%和输卵管阻塞的54.7%.
- 治疗alfa corifollitropin与子宫内膜异位症组中更高的怀孕率有关.
结论:
- 子宫内膜异位症患者的试管婴儿怀孕率低于管道阻塞患者.
- 反穆勒尔激素 (AMH) 和患者年龄是试管婴儿成功的重要独立预测因素.
- 科里福利特罗平阿尔法可能是改善子宫内膜异位症妇女体外受精结果的有益性淋巴激素.
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