在患有全身性硬化症的患者中,心脂肪组织
Xu Wang1,2, Steele C Butcher1,3, Rinchyenkhand Myagmardorj4
1Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands.
European heart journal. Imaging methods and practice
|July 24, 2024
概括
心脂肪组织 (EAT) 与心脏功能受损和系统性硬化症 (SSc) 患者的死亡率增加有关. 较高的EAT质量预测更糟糕的结果,突出其在SSc心血管并发症中的作用.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 医疗成像医学成像
背景情况:
- 心脂肪组织 (EAT) 参与心血管疾病的发病.
- 系统性硬化症 (SSc) 与心血管风险增加有关.
- 在SSc中EAT在心脏参与中的作用需要进一步阐明.
研究的目的:
- 调查SSc患者的EAT和左心室 (LV) 功能之间的关联.
- 评估SSc.中的EAT的预后意义.
- 确定EAT是否是SSc.死亡率的独立预测因素.
主要方法:
- 前性研究包括230名SSc患者.
- 使用非对比胸部计算机断层扫描量化EAT质量.
- 通过心声回声学评估LV功能.
- 对所有死因的随访时间均为8年.
主要成果:
- 增加的EAT质量 (≥67g) 与LV透析功能受损有关.
- 经调整后,EAT质量仍然与LV透析参数独立相关.
- 患有较高EAT质量的患者具有显著更高的全因死亡率 (29%vs7%).
- 在多变量分析中,EAT是所有原因死亡率的独立预测指标.
结论:
- 心脂肪组织与SSc患者的左心室透静功能障碍独立相关.
- 增加的EAT质量是SSc.中增加全因死亡率的重要预测因素.
- 在SSc.中,EAT可以作为心血管风险分层的有价值生物标志物.
更多相关视频
06:56Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue
Published on: July 21, 2023
2.1K
10:37Author Spotlight: Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration
Published on: June 9, 2023
3.0K
相关概念视频
Hypodermis
4.3K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
4.3K
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
