扩大周血管空间与无痴呆症老年人认知功能的关联:基于人口的研究
Mingqing Zhao1,2, Yuanjing Li3, Xiaodong Han4
1Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong P. R. China.
Alzheimer's & dementia (Amsterdam, Netherlands)
|July 24, 2024
概括
基础性质中扩大的周血管空间与老年人的认知能力下降有关,但这种联系主要是由于其他小血管疾病标志物. 然而,在APOE ε4载体中,中心半形EPVS仍然影响口语流.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 放射学 放射学是一门学科.
背景情况:
- 周周血管扩大空间 (EPVS) 越来越多地被认为是脑小血管疾病 (CSVD) 的标志物.
- 老年人EPVS和认知功能之间的关系需要进一步澄清.
- 了解这些关联对于识别有认知障碍风险的个体至关重要.
研究的目的:
- 研究不同大脑区域的EPVS与中国老年人的认知表现之间的关联.
- 确定其他CSVD标记是否调解EPVS和认知之间的关系.
- 探索与APOE ε4.4等遗传因素的潜在相互作用.
主要方法:
- 来自MIND-中国MRI子研究中的1191名没有痴呆症的中国老年人 (年龄≥60岁) 的基于人口的研究.
- 在基底 (BG) 和半骨中心 (CSO) 的EPVS视觉评估,以及其他CSVD标志物 (WMHs,缺口,CMBs, siderosis).
- 综合的神经心理测试电池和数据分析的一般线性模型.
主要成果:
- 较大的BG-EPVS负载与较低的记忆,语言流性和全球认知分数相关.
- 这些BG-EPVS关联在对其他CSVD标记进行调整后变得无意义.
- CSO-EPVS负载与整体认知分数没有显著的关联,除了APOE ε4载体,即使在调整CSVD标志物后,它也与较低的口语流度有关.
结论:
- 老年人BG-EPVS的认知影响在很大程度上是由同时出现的CSVD标志物解释的.
- 在APOE ε4载体中,CSO-EPVS可能与认知功能,特别是语言流性有明显的关联.
- 这些发现突出了不同CSVD病理和认知衰老之间的复杂相互作用.
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