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在晚期黑色素瘤中透瘤的淋巴细胞和免疫相关的不良事件

I A J van Duin¹, M Schuiveling¹, L S Ter Maat²

¹Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht.

Immuno-oncology technology

|July 24, 2024

概括

瘤透性淋巴细胞 (TILs) 在接受免疫检查点抑制剂治疗的晚期黑色素瘤患者中不能预测严重的免疫相关不良事件 (irAEs). 在初级或转移性黑色素瘤样本中,TIL的丰富性与irAE的发展或时间没有关联.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

瘤透淋巴细胞 (TILs) 对癌症免疫治疗中的免疫相关不良事件 (irAEs) 的预测价值尚不清楚.
已经假设瘤免疫性和irAEs之间的关联,促使对TILs作为潜在生物标志物的研究.

研究的目的:

调查TIL在治疗前的原发性和转移性黑色素瘤样本中的丰度与随后发生的严重irAEs之间的联系.
确定TIL得分是否可以预测接受一线免疫检查点抑制剂的患者中严重的IRE的发生和时间.

主要方法:

对接受抗PD-1或抗PD-1+抗CTLA-4治疗的晚期皮肤黑色素瘤患者的回顾性分析.
在初级和预处理转移标本的H&E斑点上得分TIL (缺席,非急性,急性).
统变物流回归和细分和灰分区危险模型被用来评估TIL和严重的irAEs之间的关联.

主要成果:

在原发性黑色素瘤样本中的TIL得分和等级≥3的irAEs (P=0.70) 的发展之间没有发现显著的关联.
在治疗前转移样本中,TIL的丰度也与严重的irAE发生没有关联 (P=0.91).
与没有TIL的患者相比,活跃TIL的患者在初级或转移样本中没有更高的发病率.

结论:

从原发性或转移性黑色素瘤的H&E染色幻灯片上的TIL得分不能预测严重的IRE (3级或更高) 的发展.
TILs的存在或不存在与irAE发作的时间没有相关性.
在这个患者队列中,TILs不是可靠的生物标志物来预测irAEs.

关键词:

与免疫相关的不良事件.免疫疗法免疫疗法黑色素瘤是一种黑色素瘤.病理学的病理学透到瘤中的淋巴细胞

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