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Updated: Jun 19, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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基因预测的代谢物调解了自身免疫甲状腺炎和免疫细胞之间的因果关系

Yongzhao Chen1, Bo Jiang2, Cheng Qu2

  • 1Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Frontiers in endocrinology
|July 24, 2024
PubMed
概括

这项研究发现了特定免疫细胞特征和自身免疫甲状腺炎 (AIT) 之间的因果关系,代谢物部分调解这些影响. 这些发现为AIT提供了洞察力.

关键词:
门德尔的随机化自免疫性甲状腺炎的发生.免疫细胞 免疫细胞调解的效果是调解的影响.代谢产物的代谢产物

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相关概念视频

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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