通过阴道微生态评估系统评估阴道微生物组作为体外受精结果的预测指标:一项回顾性研究
Quan Tian1,2, Shengxi Jin1, Guangmin Zhang1
1Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, Shandong, China.
Frontiers in endocrinology
|July 24, 2024
概括
阴道微生态评估系统 (VMES) 在体外受精和胚胎移植 (IVF-ET) 期间有效监测阴道微生物组 (VM) 变化,预测妊娠结果和活产率.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 微生物学 微生物学
- 医疗技术 医疗技术 医学技术
背景情况:
- 阴道微生物群 (VM) 在生殖健康中起着至关重要的作用.
- 了解体外受精和胚胎移植 (IVF-ET) 期间的VM动态对于提高成功率至关重要.
- 现有的方法可能无法完全捕捉在生育治疗期间VM的动态变化.
研究的目的:
- 评估阴道微生态评估系统 (VMES) 在评估IVF-ET期间的VM动态方面的有效性.
- 探索特定VM生态和IVF-ET成功率之间的相关性.
- 确定IVF-ET患者活产率的预测因素.
主要方法:
- 对接受第一个输卵管因子IVF-ET的不育妇女的回顾性分析 (2018年1月 - 2021年12月).
- 使用VMES评估控制卵巢刺激 (COS) 之前和之后的VM组成.
- 分析了怀孕结果,包括活产率和早期流产率,使用多变量逻辑回归.
主要成果:
- 在患有细菌性阴道炎 (BV) 的患者中,VMES准确预测了IVF-ET结果.
- 很大一部分患者在COS后表现出VM转移,BV和dysbiosis的患病率增加.
- 在COS前和后的VM状态,患者年龄和胚胎移植数量独立预测了活产率.
结论:
- 在IVF-ET期间,VMES可以有效地检测动态VM变化.
- 在IVF-ET期间的VM变化与妊娠结果有显著的相关性.
- VM状态是IVF-ET成功的一个有价值的预测指标.
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