灰色物质与衰老相关的星病:与大脑病理和认知衰退的关联
Sonal Agrawal1,2, Lei Yu1,3, Sue E Leurgans1,3
1Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
Brain : a journal of neurology
|July 24, 2024
概括
在上额叶皮层的灰色物质与衰老相关的星质病 (ARTAG) 与老年人中阿尔茨海默氏症痴呆症和认知衰退有关. 这一发现澄清了ARTAG在与年龄相关的认知障碍中的作用.
科学领域:
- 神经病理学神经病理学
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
背景情况:
- 灰色物质与衰老相关的星病 (ARTAG) 在老年大脑中很普遍,但其临床关联尚不清楚.
- 了解ARTAG与阿尔茨海默氏症和认知衰退的联系对于衰老研究至关重要.
研究的目的:
- 调查灰质ARTAG病理与阿尔茨海默病 (AD) 和其他与年龄有关的蛋白质病变的关联.
- 确定灰色物质ARTAG与阿尔茨海默氏症痴呆症和认知衰退等临床表型之间的关系.
主要方法:
- 从纵向社区研究中检查了442名死者 (平均年龄为90岁).
- 评估灰色物质ARTAG严重程度使用AT8免疫组织化学在上额叶皮质,前尖和杏仁体.
- 评估了阿尔茨海默氏症,其他神经病理,阿尔茨海默氏症痴呆症诊断和全球和特定领域的认知表现.
主要成果:
- 灰质ARTAG病理存在于73%的参与者中,最常见的是杏仁体 (68%).
- ARTAG与病理性阿尔茨海默病和TAR DNA结合蛋白43脑病变有关,但与血管病变无关.
- 在上额叶皮质中增加ARTAG严重程度,而不是杏仁体或前尖,与阿尔茨海默氏症痴呆的更高几率和全球认知,情节性记忆和语义记忆的更快认知衰退相关.
结论:
- 灰质ARTAG,特别是在上额叶皮层,显著促进阿尔茨海默氏症痴呆和与年龄相关的认知衰退.
- 这些发现强调了老化大脑中特定ARTAG位置的临床相关性.
相关概念视频
01:26Alzheimer's Disease: Overview
456
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
456
01:26Aging
41
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
41
03:03Amyloid Fibrils
9.5K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.5K
01:30Cognitive Development During Adulthood
76
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
76
01:30Dementia
110
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
110