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18F-FDG PET/CT用于早期预测乳腺癌新辅助治疗中的病理完整反应:一个回顾性分析

Yilin Wu¹, Yanling Li², Bin Chen¹

¹Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, People's Republic of China.

|July 24, 2024

概括

早期的2-deoxy-2-[F-18]-d-glucose (18F-FDG) 定子发射断层扫描 (PET) /计算机断层扫描 (CT) 扫描变化可以预测接受新辅助治疗 (NAT) 的乳腺癌患者的病理完整反应 (pCR). 这种成像方法有助于早期识别治疗敏感个体.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
医疗成像医学成像

背景情况:

新辅助治疗 (NAT) 改善了早期乳腺癌的结果,但早期识别治疗反应是具有挑战性的.
延迟反应的识别可能会导致治疗期间疾病的进展.
准确的治疗敏感性的早期预测对于优化患者管理至关重要.

研究的目的:

评估二氧化二-[F-18]-d-葡萄糖 (18F-FDG) 定子发射断层扫描 (PET) /计算机断层扫描 (CT) 在预测早期乳腺癌患者的病理完整反应 (pCR) 的疗效.
开发和验证基于18F-FDG PET/CT的模型,用于早期预测治疗反应.

主要方法:

对121名接受了NAT和手术的早期乳腺癌患者的回顾性分析.
收集了基线和后续18F-FDG PET/CT扫描的初级瘤和下淋巴结的收集.
后勤回归分析以确定pCR的预测因素,并使用ROC曲线评估模型性能.

主要成果:

在18F-FDG PET/CT上最大标准吸收值 (SUVmax) 表明瘤状态;股SUVmax与转移性淋巴结数相关 (R=0.62).
早期SUVmax降低率 (基线和第二个NAT周期之间) 在pCR和非pCR组之间显著不同.
一个基于SUVmax降低率的模型在预测所有分子亚型的pCR (AUC=0.89) 中表现出高准确度.

结论:

来自18F-FDG PET/CT的SUVmax降低率是NAT早期预测乳腺癌患者的pCR的一个有价值的工具.
这些发现支持将PET/CT成像纳入未来的新辅助治疗策略,以进行个性化治疗.

关键词:

18F-FDG 关于PET/CT 的研究乳腺癌乳腺癌乳腺癌药物反应药物反应新辅助疗法是一种新辅助疗法.

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