在评估带有边际益处的癌症治疗时,患者对时间毒性的考虑
Arjun Gupta1, Michael D Brundage2, Jacqueline Galica2
1Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN, United States.
The oncologist
|July 24, 2024
概括
近一半的晚期癌症患者在决定治疗时考虑"时间毒性". 那些优先考虑时间的人更有可能拒绝没有整体生存益处的选择,强调时间是癌症护理决策的关键因素.
科学领域:
- 在瘤学瘤学.
- 抚慰性护理是一种缓解性护理.
- 决策科学 决策科学 决策科学
背景情况:
- 引起患者对癌症治疗的偏好,带有边际收益和不同的风险,在临床上具有意义.
- 了解患者对患者考虑的因素.
- 时间毒性 时间毒性
- (时间负担) 对于治疗决策至关重要.
研究的目的:
- 评估患者对时间负担的考虑与他们对假设癌症治疗的决定之间的关联.
- 探索时间毒性如何影响晚期癌症患者的治疗偏好.
主要方法:
- 一个多中心的二次分析,混合方法研究的息意图的癌症治疗.
- 基于在定性采访期间自发提到时间负担的参与者的分类.
- 两组之间对治疗选择的比较 (无进展自由生存 (PFS) 增长,一些PFS增长或治疗下降).
主要成果:
- 在100名晚期癌症患者中,有46%的人自发地讨论了时间负担.
- 提到时间的患者对PFS增长的门较高 (P=.004),并且更有可能在没有整体生存 (OS) 益处的情况下拒绝治疗 (65%对31%).
- 定性分析显示,时间负担受治疗因素的影响,并显著影响患者的决策.
结论:
- 时间负担是近一半做出假设癌症治疗决定的患者的重要考虑因素.
- 考虑时间负担的患者表现出明显的治疗偏好,特别是在没有OS益处的治疗方面.
- 临床医生和决策科学研究人员应将时间负担作为癌症护理研究和临床实践的关键属性.
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