利用艾滋病毒和淋巴瘤新生病患者的跨学科管理
Carolina Celades1,2, Montse Tuset3, Juan Ambrosioni4,5
1Lymphoid Neoplasms Group, Josep Carreras Laukaemia Research Institute, Badalona, Spain.
The Journal of antimicrobial chemotherapy
|July 24, 2024
概括
优化抗逆转录病毒治疗 (ART) 在艾滋病毒感染者 (PWH) 癌症患者中至关重要. 使用未增强的ART和跨学科管理改善了接受化疗的PWH的存活率.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗逆转录病毒治疗 (ART) 和化疗之间的药物相互作用可能会对患有癌症的艾滋病毒感染者 (PWH) 的结果产生负面影响.
- 对这些相互作用的管理对于改善患者预后至关重要.
研究的目的:
- 评估跨学科管理和ART类型如何影响淋巴瘤瘤的PWH的结果.
- 分析协作护理模式对治疗疗效的影响.
主要方法:
- 一个多中心的,追溯的观察队列研究,对118名在2008-2020年期间被诊断患有淋巴瘤瘤的PWH进行了观察.
- 对与5年无进展生存 (PFS) 和整体生存 (OS) 相关的人口,临床和治疗变量的分析.
- 考克斯的比例危险模型被用来评估生存结果.
主要成果:
- 在诊断时增加的ART使用与更糟糕的5年PFS和OS有关.
- 跨学科的管理导致增强型ART的使用减少,并增加了基于整合酶链转移抑制剂的ART的使用.
- 通过跨学科管理观察到改善PFS和OS的趋势,特别是对于那些在诊断时接受增强ART的人来说.
结论:
- ART的类型显著影响了接受化疗的PWH的预后.
- 参与瘤学家,药剂师和艾滋病毒专家的合作管理改善了癌症PWH中的PFS和OS率.
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