与代谢功能障碍相关的脂肪性肝病的患病率和第三级中心炎症性肠病的危险因素
Lívia Dos Remédios Pamplona de Oliveira1, Tarsila Campanha da Rocha Ribeiro1, Carlos Alberto Mourao Junior2
1Universidade Federal de Juiz de Fora, Hospital Universitário - Juiz de Fora (MG), Brazil.
Revista da Associacao Medica Brasileira (1992)
|July 24, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 在炎症性肠病 (IBD) 患者中很常见. 代谢综合征的组成部分,而不是IBD特征,是MASLD的关键风险因素.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 代谢疾病 代谢疾病
背景情况:
- 炎症性肠病 (IBD) 影响全球数百万人,增加了对其他慢性疾病的易感性.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个越来越令人担忧的疾病,特别是在患有慢性炎症疾病的患者中.
- 了解IBD和MASLD之间的相互作用对于全面的患者管理至关重要.
研究的目的:
- 为了确定成人IBD患者中MASLD的患病率.
- 在这个人群中识别与MASLD相关的风险因素.
- 区分IBD相关的和导致MASLD的代谢因素.
主要方法:
- 一项涉及2019-2021年成人IBD患者的横截面研究.
- MASLD定义为肝硬化症加上至少一个心脏代谢风险因素.
- 排除标准包括重度饮酒,其他慢性肝病和甲状腺素使用.
主要成果:
- 在研究的近140名IBD患者中,MASLD在44.3%的患者中存在.
- MASLD患者年龄较大,具有更多的代谢综合征成分,更大的腰围和更高的BMI.
- IBD疾病的持续时间,但不是IBD特征或治疗,与MASLD有关.
结论:
- 在IBD患者中,MASLD的患病率很高.
- 代谢综合征的组成部分是IBD中MASLD的显著预测因素.
- 在IBD患者中,MASLD风险主要是由代谢因素驱动的,独立于IBD特征.
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