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在帕金森病中脑下丘脑核深度刺激后的精神疾病:系统性审查
Caio de Almeida Lellis1, Marco Alejandro Menacho Herbas1, Ledismar José da Silva1
1Escola de Ciências Médicas e da Vida, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brazil.
Einstein (Sao Paulo, Brazil)
|July 24, 2024
概括
对帕金森病的深度大脑刺激可能会导致精神变化. 抑郁症是最常见的,但由于手术,躁狂,精神病和焦虑也会发生.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经外科 神经外科
背景情况:
- 帕金森病 (PD) 是一种神经退行性疾病.
- 深度大脑刺激 (DBS) 是一种手术治疗PD的方法.
- 脑下细胞核 (STN) DBS是一种常见的治疗方法.
研究的目的:
- 为了评估STN DBS后在PD患者中发生的精神病变化.
- 为了确定精神病副作用的类型和频率.
主要方法:
- 进行了对文章的系统审查.
- 在公共/出版商MEDLINE,虚拟健康图书馆和Cochrane图书馆中进行了搜索.
- 十一项研究符合纳入标准.
主要成果:
- 抑郁症是最常见的精神病并发症 (5/11项研究,26名患者).
- 躁狂/低躁狂发生在2项研究中.
- 精神病和过度性行为与其他精神问题相关报道.
结论:
- STN DBS可以导致PD患者的各种精神疾病.
- 观察到的变化可能与微损伤或刺激参数有关.
- 通常报告的问题包括抑郁症,躁狂/催眠症,精神病,焦虑和自杀念头.
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